Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial.
Identifieur interne : 001B81 ( Main/Exploration ); précédent : 001B80; suivant : 001B82Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial.
Auteurs : Marc P. Bonaca [États-Unis] ; Deepak L. Bhatt [États-Unis] ; Ton Oude Ophuis [Pays-Bas] ; P Gabriel Steg [France] ; Robert Storey [Royaume-Uni] ; Marc Cohen [États-Unis] ; Julia Kuder [États-Unis] ; Kyungah Im [États-Unis] ; Giulia Magnani [États-Unis] ; Andrzej Budaj [Pologne] ; Pierre Theroux [Canada] ; Christian Hamm [Allemagne] ; Jindrich Špinar [République tchèque] ; Robert G. Kiss [Hongrie] ; Anthony J. Dalby [Afrique du Sud] ; Felix A. Medina [Pérou] ; Frederic Kontny [Norvège] ; Philip E. Aylward [Australie] ; Eva C. Jensen [Suède] ; Peter Held [Suède] ; Eugene Braunwald [États-Unis] ; Marc S. SabatineSource :
- JAMA cardiology [ 2380-6591 ] ; 2016.
Abstract
In the PEGASUS-TIMI 54 trial, treatment with ticagrelor reduced the incidence of cardiovascular death, myocardial infarction, or stroke by 15% to 16% among stable patients compared with placebo. However, more patients prematurely discontinued treatment with ticagrelor than with placebo.
DOI: 10.1001/jamacardio.2016.1017
PubMed: 27438319
Affiliations:
- Afrique du Sud, Allemagne, Australie, Canada, France, Hongrie, Norvège, Pays-Bas, Pologne, Pérou, Royaume-Uni, République tchèque, Suède, États-Unis
- Angleterre, Gueldre, Hongrie centrale, Massachusetts, Moravie, New Jersey, Île-de-France
- Brno, Budapest, Nimègue, Paris
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001B71
- to stream PubMed, to step Curation: 001B47
- to stream PubMed, to step Checkpoint: 001B47
- to stream Ncbi, to step Merge: 003873
- to stream Ncbi, to step Curation: 003873
- to stream Ncbi, to step Checkpoint: 003873
- to stream Main, to step Merge: 001B78
- to stream Main, to step Curation: 001B81
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial.</title><author><name sortKey="Bonaca, Marc P" sort="Bonaca, Marc P" uniqKey="Bonaca M" first="Marc P" last="Bonaca">Marc P. Bonaca</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Oude Ophuis, Ton" sort="Oude Ophuis, Ton" uniqKey="Oude Ophuis T" first="Ton" last="Oude Ophuis">Ton Oude Ophuis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CWZ Hospital, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, CWZ Hospital, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P Gabriel" last="Steg">P Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Département Hospitalo Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France4Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département Hospitalo Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France4Université Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Storey, Robert" sort="Storey, Robert" uniqKey="Storey R" first="Robert" last="Storey">Robert Storey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Science, University of Sheffield, Sheffield, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Cardiovascular Science, University of Sheffield, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Division, Newark Beth Israel Medical Center, Rutgers-New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Cardiovascular Division, Newark Beth Israel Medical Center, Rutgers-New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Kuder, Julia" sort="Kuder, Julia" uniqKey="Kuder J" first="Julia" last="Kuder">Julia Kuder</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Im, Kyungah" sort="Im, Kyungah" uniqKey="Im K" first="Kyungah" last="Im">Kyungah Im</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Magnani, Giulia" sort="Magnani, Giulia" uniqKey="Magnani G" first="Giulia" last="Magnani">Giulia Magnani</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Hamm, Christian" sort="Hamm, Christian" uniqKey="Hamm C" first="Christian" last="Hamm">Christian Hamm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany10University of Giessen, Giessen, Hesse, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany10University of Giessen, Giessen, Hesse</wicri:regionArea><wicri:noRegion>Hesse</wicri:noRegion><wicri:noRegion>Hesse</wicri:noRegion><wicri:noRegion>Hesse</wicri:noRegion></affiliation></author><author><name sortKey="Spinar, Jindrich" sort="Spinar, Jindrich" uniqKey="Spinar J" first="Jindrich" last="Špinar">Jindrich Špinar</name><affiliation wicri:level="3"><nlm:affiliation>Internal Cardiology Department, University Hospital and Medical Faculty, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Internal Cardiology Department, University Hospital and Medical Faculty, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kiss, Robert G" sort="Kiss, Robert G" uniqKey="Kiss R" first="Robert G" last="Kiss">Robert G. Kiss</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Military Hospital, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Cardiology, Military Hospital, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Dalby, Anthony J" sort="Dalby, Anthony J" uniqKey="Dalby A" first="Anthony J" last="Dalby">Anthony J. Dalby</name><affiliation wicri:level="1"><nlm:affiliation>South African Cardiology Clinical Trials Group, Milpark Hospital, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>South African Cardiology Clinical Trials Group, Milpark Hospital, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Medina, Felix A" sort="Medina, Felix A" uniqKey="Medina F" first="Felix A" last="Medina">Felix A. Medina</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Clínicas Médicas, Hospital Nacional Cayetano Heredia, San Martin de Porres, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Departamento de Clínicas Médicas, Hospital Nacional Cayetano Heredia, San Martin de Porres, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Kontny, Frederic" sort="Kontny, Frederic" uniqKey="Kontny F" first="Frederic" last="Kontny">Frederic Kontny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Eva C" sort="Jensen, Eva C" uniqKey="Jensen E" first="Eva C" last="Jensen">Eva C. Jensen</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca Research and Development, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>AstraZeneca Research and Development, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Held, Peter" sort="Held, Peter" uniqKey="Held P" first="Peter" last="Held">Peter Held</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca Research and Development, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>AstraZeneca Research and Development, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Braunwald, Eugene" sort="Braunwald, Eugene" uniqKey="Braunwald E" first="Eugene" last="Braunwald">Eugene Braunwald</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><affiliation><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts18Deputy Editor, JAMA Cardiology.</nlm:affiliation><wicri:noCountry code="subField">JAMA Cardiology</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27438319</idno><idno type="pmid">27438319</idno><idno type="doi">10.1001/jamacardio.2016.1017</idno><idno type="wicri:Area/PubMed/Corpus">001B71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B71</idno><idno type="wicri:Area/PubMed/Curation">001B47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B47</idno><idno type="wicri:Area/PubMed/Checkpoint">001B47</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B47</idno><idno type="wicri:Area/Ncbi/Merge">003873</idno><idno type="wicri:Area/Ncbi/Curation">003873</idno><idno type="wicri:Area/Ncbi/Checkpoint">003873</idno><idno type="wicri:Area/Main/Merge">001B78</idno><idno type="wicri:Area/Main/Curation">001B81</idno><idno type="wicri:Area/Main/Exploration">001B81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial.</title><author><name sortKey="Bonaca, Marc P" sort="Bonaca, Marc P" uniqKey="Bonaca M" first="Marc P" last="Bonaca">Marc P. Bonaca</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Oude Ophuis, Ton" sort="Oude Ophuis, Ton" uniqKey="Oude Ophuis T" first="Ton" last="Oude Ophuis">Ton Oude Ophuis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CWZ Hospital, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, CWZ Hospital, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P Gabriel" last="Steg">P Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Département Hospitalo Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France4Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département Hospitalo Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France4Université Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Storey, Robert" sort="Storey, Robert" uniqKey="Storey R" first="Robert" last="Storey">Robert Storey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Science, University of Sheffield, Sheffield, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Cardiovascular Science, University of Sheffield, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Division, Newark Beth Israel Medical Center, Rutgers-New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Cardiovascular Division, Newark Beth Israel Medical Center, Rutgers-New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Kuder, Julia" sort="Kuder, Julia" uniqKey="Kuder J" first="Julia" last="Kuder">Julia Kuder</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Im, Kyungah" sort="Im, Kyungah" uniqKey="Im K" first="Kyungah" last="Im">Kyungah Im</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Magnani, Giulia" sort="Magnani, Giulia" uniqKey="Magnani G" first="Giulia" last="Magnani">Giulia Magnani</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Hamm, Christian" sort="Hamm, Christian" uniqKey="Hamm C" first="Christian" last="Hamm">Christian Hamm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany10University of Giessen, Giessen, Hesse, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany10University of Giessen, Giessen, Hesse</wicri:regionArea><wicri:noRegion>Hesse</wicri:noRegion><wicri:noRegion>Hesse</wicri:noRegion><wicri:noRegion>Hesse</wicri:noRegion></affiliation></author><author><name sortKey="Spinar, Jindrich" sort="Spinar, Jindrich" uniqKey="Spinar J" first="Jindrich" last="Špinar">Jindrich Špinar</name><affiliation wicri:level="3"><nlm:affiliation>Internal Cardiology Department, University Hospital and Medical Faculty, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Internal Cardiology Department, University Hospital and Medical Faculty, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kiss, Robert G" sort="Kiss, Robert G" uniqKey="Kiss R" first="Robert G" last="Kiss">Robert G. Kiss</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Military Hospital, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Cardiology, Military Hospital, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Dalby, Anthony J" sort="Dalby, Anthony J" uniqKey="Dalby A" first="Anthony J" last="Dalby">Anthony J. Dalby</name><affiliation wicri:level="1"><nlm:affiliation>South African Cardiology Clinical Trials Group, Milpark Hospital, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>South African Cardiology Clinical Trials Group, Milpark Hospital, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Medina, Felix A" sort="Medina, Felix A" uniqKey="Medina F" first="Felix A" last="Medina">Felix A. Medina</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Clínicas Médicas, Hospital Nacional Cayetano Heredia, San Martin de Porres, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Departamento de Clínicas Médicas, Hospital Nacional Cayetano Heredia, San Martin de Porres, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Kontny, Frederic" sort="Kontny, Frederic" uniqKey="Kontny F" first="Frederic" last="Kontny">Frederic Kontny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Eva C" sort="Jensen, Eva C" uniqKey="Jensen E" first="Eva C" last="Jensen">Eva C. Jensen</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca Research and Development, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>AstraZeneca Research and Development, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Held, Peter" sort="Held, Peter" uniqKey="Held P" first="Peter" last="Held">Peter Held</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca Research and Development, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>AstraZeneca Research and Development, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Braunwald, Eugene" sort="Braunwald, Eugene" uniqKey="Braunwald E" first="Eugene" last="Braunwald">Eugene Braunwald</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><affiliation><nlm:affiliation>TIMI Study Group, Brigham and Women's Hospital Heart and Vascular Center, Boston, Massachusetts18Deputy Editor, JAMA Cardiology.</nlm:affiliation><wicri:noCountry code="subField">JAMA Cardiology</wicri:noCountry></affiliation></author></analytic><series><title level="j">JAMA cardiology</title><idno type="eISSN">2380-6591</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the PEGASUS-TIMI 54 trial, treatment with ticagrelor reduced the incidence of cardiovascular death, myocardial infarction, or stroke by 15% to 16% among stable patients compared with placebo. However, more patients prematurely discontinued treatment with ticagrelor than with placebo.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Hongrie</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Pérou</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Gueldre</li><li>Hongrie centrale</li><li>Massachusetts</li><li>Moravie</li><li>New Jersey</li><li>Île-de-France</li></region><settlement><li>Brno</li><li>Budapest</li><li>Nimègue</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Bonaca, Marc P" sort="Bonaca, Marc P" uniqKey="Bonaca M" first="Marc P" last="Bonaca">Marc P. Bonaca</name></region><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><name sortKey="Braunwald, Eugene" sort="Braunwald, Eugene" uniqKey="Braunwald E" first="Eugene" last="Braunwald">Eugene Braunwald</name><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name><name sortKey="Im, Kyungah" sort="Im, Kyungah" uniqKey="Im K" first="Kyungah" last="Im">Kyungah Im</name><name sortKey="Kuder, Julia" sort="Kuder, Julia" uniqKey="Kuder J" first="Julia" last="Kuder">Julia Kuder</name><name sortKey="Magnani, Giulia" sort="Magnani, Giulia" uniqKey="Magnani G" first="Giulia" last="Magnani">Giulia Magnani</name></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Oude Ophuis, Ton" sort="Oude Ophuis, Ton" uniqKey="Oude Ophuis T" first="Ton" last="Oude Ophuis">Ton Oude Ophuis</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P Gabriel" last="Steg">P Gabriel Steg</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Storey, Robert" sort="Storey, Robert" uniqKey="Storey R" first="Robert" last="Storey">Robert Storey</name></region></country><country name="Pologne"><noRegion><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Hamm, Christian" sort="Hamm, Christian" uniqKey="Hamm C" first="Christian" last="Hamm">Christian Hamm</name></noRegion></country><country name="République tchèque"><region name="Moravie"><name sortKey="Spinar, Jindrich" sort="Spinar, Jindrich" uniqKey="Spinar J" first="Jindrich" last="Špinar">Jindrich Špinar</name></region></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Kiss, Robert G" sort="Kiss, Robert G" uniqKey="Kiss R" first="Robert G" last="Kiss">Robert G. Kiss</name></region></country><country name="Afrique du Sud"><noRegion><name sortKey="Dalby, Anthony J" sort="Dalby, Anthony J" uniqKey="Dalby A" first="Anthony J" last="Dalby">Anthony J. Dalby</name></noRegion></country><country name="Pérou"><noRegion><name sortKey="Medina, Felix A" sort="Medina, Felix A" uniqKey="Medina F" first="Felix A" last="Medina">Felix A. Medina</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Kontny, Frederic" sort="Kontny, Frederic" uniqKey="Kontny F" first="Frederic" last="Kontny">Frederic Kontny</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Jensen, Eva C" sort="Jensen, Eva C" uniqKey="Jensen E" first="Eva C" last="Jensen">Eva C. Jensen</name></noRegion><name sortKey="Held, Peter" sort="Held, Peter" uniqKey="Held P" first="Peter" last="Held">Peter Held</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B81 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B81 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27438319
|texte= Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27438319" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |